Cover: “Developing Megalops” by Chris Rieken, research assistant in the MBL’s Bay Paul Center. This polarized light image of a larval crab in the final stage of development, known as megalops, won first place in the 2009 MBL Scientific Photography Content.

Inside front cover: MBL Director and CEO Gary Borisy, E. Armstrong

Table of contents: “Developing Megalops,” C. Rieken; Limulus, Xenopus, Loligo illustrations, B. Harmon, www.barbaraharmon.com; zebrafish, Dohnal/Dreamstime.com

Pp. 2–3: (top) Catch about the MBL’s RV Gemma, MBL Logan Science Journalism Program; fisheye view of waves running ashore, Demonike/Dreamstime.com; Loligo, Opsanus, Limulus, Stronglyocentrotus, Spisula, Aplysia illustrations, B. Harmon, www.barbaraharmon.com

Pp. 4–5 (clockwise from top left): Asterias, L. Golder; Xenopus illustration, B. Harmon, www.barbaraharmon.com; Botryllus colony, T. De Tomaso

Pp. 6–7 (clockwise from top left): Patagonian Glacier, Cosmopol/Dreamstime.com; Clifford Brangwynne, A. Garbe, Zentrale für schnelle Fotoeinsätze; histopathologic image of senile plaques in the cerebral cortex in a patient with presenile onset of Alzheimer’s disease, Wikimedia Commons; Adélie penguin, T. Russer, TSGT, USAF, National Science Foundation; negative stain EM image of the 2009 H1N1 influenza A/CA/4/09, CDC/C. S. Goldsmith and A. Balish.

Pp. 8–9: Jane Lubchenco, courtesy of Oregon State University

Pp. 10–11: Danio rerio, L. Roth; Joan Ruderman and Joseph Buxbaum in the MBL’s Marine Resources zebrafish facilty, E. Armstrong; zebrafish (top right), Dohnal/Dreamstime.com

Pp. 12–13 (clockwise from top left): Jesse Ausubel, E. Armstrong; Cuttyhunk Island shoreline with rocks, E. Hebert, www.edhebert.com; sea urchin, crab, tiger, grass, Dreamstime.com; Jesse Ausubel, E. Armstrong; honeybee, Dreamstime.com

P. 14 (clockwise from top center): measuring Arctic river discharge, MBL Logan Science Journalism Program; cuttlefish, D. Remsen; firefly lantern organ stained for Luciferase (green), Nitric oxide (red), and cell nuclei dapi (blue), J. Buchanan

P. 15: MBL Ecosystems Center scientist Linda Deegan studies the Arctic grayling on the Kuparuk River, Alaska, N.E. Cohen; pit tags used to locate grayling, D. Gallagher

P. 16: MBL visiting investigator Scott Brady, E. Armstrong

P. 17: Illustration from: Joubin, Louis (1900) “Fascicule XVII: Cephalopodes provenant des campagnes de la Princesse-Alice (1891-1897),” in Resultats des Campagnes Scientifiques Accomplies sur Son Yacht par Albert Ier, Prince Souverain de Monaco. PL III. The octopi are now known as Pteroctopus tetracirrhus (top), Benthoctopus levis (bottom), and Grimpoteuthis umbellata (side diagrams).

Back page: MBL director Gary Borisy, WHOI director Susan Avery, and WHRC acting director Richard Houghton shake hands after signing the Memorandum of Agreement creating the Woods Hole Consortium, T. Kleindinst; MBL scientists aboard a Zodiak near Palmer Station Antarctica, C. Sucher; MBL scientists prepare for field sampling in Panama, I. Valiela; breaking ground for renovations to the MBL’s Loeb Laboratory, T. Kleindinst.

References:

Letter from the Director (Inside front cover)

Roger Y. Tsien’s speech at the Nobel Banquet in Stockholm City Hall, Dec. 10, 2008:

http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/tsien-speech.html

Introduction (Pp. 2-3)

Sanford, G.M., W.I. Lutterschmidt, and V.H. Hutchison (2002) The comparative method revisited. BioScience 52: 830-836.

It’s Back! (Pp. 4-5)

MBL Frontiers in Stem Cells and Regeneration Course:
http://www.mbl.edu/education/courses/special_topics/scare.html

Poss, K.D., et al. (2002) Heart regeneration in zebrafish. Science 298: 21882190

Sánchez Alvarado, A. (2009) A cellular view of regeneration. Nature 460: 39-40.

Stocum, D.L (2004) Regenerative biology and medicine: An overview. Cellscience Reviews 1: ISSN 1742-8130.

News & Notes (Pp. 6-7)4

Brangwynne, C.P., et al (2009) Germline p granules are liquid droplets that localize by controlled dissolution/condensation. Science 324: 1729-1732.

Karl, T.J, J. M. Melillo, and T.C. Peterson, eds. Global Climate Change Impacts in the United States. Cambridge University Press, 2009. (This report is available for download at www.globalchange.gov)

Kozul, C.D., et al (2009) Low dose arsenic compromises the immune response to influenza infection in vivo. Environ. Health Perspect. 117: 1108-1115.

Montes-Hugo, M., et al (2009) Recent changes in phytoplankton communities associated with rapid regional climate change along the Western Antarctic Peninsula. Science 323, 1470-1473.

Moreno, H. et al (2009) Synaptic transmission block by presynaptic injection of oligomeric amyloid beta. PNAS 106: 5901-5906.

Pigino, G., et al (2009) Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. PNAS 106: 5907-5912.

Steward of the Seas (Pp. 8-9)

Levin, S.A. and J. Lubchenco (2008) Resilience, Robustness, and Marine Ecosystem-based Management. BioScience 58: 27-32.

Testimony of Dr. Jane Lubchenco, Senate Commerce Committee, February 12, 2009:
www.legislative.noaa.gov/Testimony/Lubchenco021209.pdf

Vitousek, P.M., et al (1997) Human Domination of Earth’s Ecosystems. Science 277: 494-499.

One Fish, Many Hats (Pp. 10-11)

MBL Zebrafish Development and Genetics Course:
http://www.mbl.edu/education/courses/special_topics/zebra.html

Hoistad, M., et al (2009) Linking white and grey matter in schizophrenia:
oligodendrocyte and neuron pathology in the prefrontal cortex. Frontiers in Neuroanatomy 3: 1-15.

Grunwald, D.J. and J.S. Eisen (2002) Headwaters of the zebrafish – emergence of a new model vertebrate. Nature 3: 717.

The Big Picture (Pp. 12-13)

Census of Marine Life
http://www.coml.org/

International Census of Marine Microbes
http://icomm.mbl.edu/

Encyclopedia of Life
http://www.eol.org

Ausubel, Jesse H. (2007) Telescopes, Microscopes, Macroscopes and DNA Barcodes.
http://barcoding.si.edu/PDF/Banbury3%20-%20Ausubel%20Macroscopes.doc

Signals from the Squid (P. 16)

Pigino, G., et al (2009) Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. PNAS 106: 5907-5912.

Morfini, G.A., et al (2009) Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci. 12: 864-871.

Memorabilia (P. 17)

Full text of Resultats des Campagnes Scientifiques Accomplies sur Son Yacht par Albert Ier, Prince Souverain de Monaco available online through the Biodiversity Heritage Library: http://www.biodiversitylibrary.org/