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The Irvin Isenberg Memorial Lecture
7/3/09 - 9:00 AM, Lillie Auditorium
"Breakthroughs in Imaging Using Photoactivatable Fluorescent Protein Technology"
Jennifer Lippincott-Schwartz, NIH
Dr. Jennifer Lippincott-Schwartz attended Swarthmore College graduating with honors in 1974. After several years of teaching in Kenya and California, she turned to laboratory research working with Dr. Phil Hanwalt at Stanford University receiving a Master's degree in Biology in 1979. Dr. Lippincott-Schwartz then entered the Ph.D. Program in Biology at Johns Hopkins University studying under the mentorship of Dr. Douglas Fambrough. After doing post-doctoral work in the laboratory of Richard Klausner at the National Institutes of Health in Bethesda, Maryland, she established her own lab at the National Institutes of Health and is now Chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Dr. Lippincott-Schwartz uses live cell imaging approaches to analyze the spatio-temporal behavior and dynamic interactions of molecules in cells. These approaches have helped to change the conventional 'static' view of protein distribution and function in cells to a more dynamic view that integrates information on protein localization, concentration, diffusion and interactions that are indiscernible from protein sequences and in vitro biochemical experiments alone. Dr. Lippincott-Schwartz's projects cover a vast range of cell biological topics, including protein transport and the cytoskeleton, organelle assembly and disassembly, and the generation of cell polarity. Analysis of the dynamics of fluorescently labeled proteins expressed in cells is performed using numerous live cell imaging approaches, including FRAP, FCS and photoactivation. Most recently, her research employs photoactivated localization microscopy, called PALM, that enables visualization of molecule distributions at high density at the nano-scale. Dr. Lippincott-Schwartz serves as Editor for Current Protocols in Cell Biology and The Journal of Cell Science and she is on the Editorial Boards of Cell, Molecular Biology of the Cell and Traffic. She is an active member of the scientific community, serving as a member of the Council for the American Society of Cell Biology and on the Executive Board of the Biophysical Society. In 2008, she became a fellow of the American Association for the Advancement of Science (AAAS) and was elected to the National Academy of Sciences.
About the Irvin Isenberg Memorial Lecture
The Irvin Isenberg Memorial Lecture was established in memory of Dr. Isenberg, whose distinguished career as a biophysicist began at the Marine Biological Laboratory.
In 1950, Dr. Isenberg completed his Ph.D. in physics at the University of Pennsylvania and later developed an interest in biophysics while serving as a lecturer at the University of Chicago. In 1957, Dr. Isenberg and his family moved to Woods Hole, where he joined Nobel Laureate Albert Szent-Györgyi in his Institute for Muscle Research. Together they studied charge transfer reactions and free radicals using one of the early electron spin resonance instruments available in the United States. Dr. Isenberg also conducted research on fluorescence and phosphorescence of DNA before leaving the MBL in 1965 to become Professor of Biophysics and Biochemistry at Oregon State University. There he developed his primary research interest in the structure and function of histones.
The Isenberg family returned to Woods Hole every summer to rejoin beloved friends and to remain active participants in the scientific life of the community. Dr. Isenberg devoted his life to science and is remembered for instilling a strong sense of intellectual curiosity and integrity in the pursuit of scientific truth among his students. Today, we celebrate Dr. Isenberg’s legacy by dedicating this lecture in his honor.
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