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Colloquium on the Biology of Aging
August 16 - 18, 2007

Sponsored by The Ellison Medical Foundation and the Marine Biological Laboratory

All seminars are held in the Lillie Auditorium.

Public parking available in the MBL's Bar Neck Road lot,
33 Bar Neck Road, across from the Woods Hole Yacht Club.

Thursday, August 16
8:15 - 8:30 Introductions


8:30 - 9:15 Priyamvada Rai, Ph.D. (Weinberg lab)
Whitehead Institute for Biomedical Research
Defining a Role for Oxidative Stress in the Induction of Cellular Aging


9:15 - 10:00 Victoria Lundblad, Ph.D.
Salk Institute for Biological Studies
Translating Yeast Telomere Biology to Human Cells: Identification of Activities that Regulate Human Telomere Maintenance and Cellular Proliferation


10:00 - 10:30 Break


10:30 - 11:15 Ronald A. DePinho, M.D.
Dana-Farber Cancer Institute
The Genetic Role of Telomere Dynamics and DNA Damage Response in Stem Cell Depletion, Organ Homeostasis and Aging


11:15 - 12:00 Tannishtha Reya, Ph.D.
Duke University Medical Center
Control of Stem Cell Self-renewal and Regeneration


12:00 - 1:00 Lunch


1:00 - 1:45 Vera Gorbunova, Ph.D.
University of Rochester
Evolution of Telomerase Activtity, Genome Stability, and Longevity


1:45 - 2:30 Arlan G. Richardson, Ph.D. , University of Texas Health Science Center - San Antonio; and South Texas Veteran's Health Care System Audie Murphy Division

and

Fred E. Regnier, Ph.D./co-PI , Purdue University
Development of Proteomic Tools to Identify Post-Translational Modifications in Proteins that Occur with Age


2:30 - 3:00 Break


3:00 - 3:45

Woodring Wright, M.D., Ph.D.

University of Texas Southwestern Medical Center

Therapeutic Implications of Immortalized Normal Cells



3:45 - 4:30 Frederick W. Alt, Ph.D.
Immune Disease Institute
Mouse Models of Sirtuin Deficiency



Friday, August 17
8:00 - 8:45 Ary Goldberger, Ph.D.
Beth Israel Deaconess Medical Center, Harvard Medical School
Nonequilibrium Dynamics, Time Asymmetry, and the Biology of Aging


8:45 - 9:30 Joshua R. Sanes, Ph.D.
Harvard University
Aging of the Synapse


9:30 - 10:15 Kathryn J. Moore, Ph.D.
Massachusetts General Hospital
Genetic and Functional Analysis of CD36-signaling in Age-related Chronic Inflammatory Diseases


10:15 - 10:45 Break


10:45 - 11:30 Jiyan Ma, Ph.D.
Ohio State University
The Pathogenic Mechanism of Prion Disease


11:30 - 12:15 Daniel Promislow, D.Phil.
University of Georgia
Gene Interactions, Gene Networks, and the Evolution of Aging


12:15 - 1:15 Lunch


1:15 - 2:00 Shawn Cameron Ahmed, B.S., Ph.D.
University of North Carolina - Chapel Hill
Germline Immortality in C. elegans


2:00 - 2:45 Olivia M. Pereira-Smith, Ph.D.
University of Texas Health Science Center - San Antonio
The Role of the MORF/MRG Family of Novel Transcription Factors in In Vitro and In Vivo Aging


2:45 - 3:30 Shuji Kishi, M.D., Ph.D.
Schepens Eye Research Institute, Harvard Medical School
Genetic Approaches for Functional Aging in Zebrafish


8:00 PM Friday Evening Lecture
Craig Mello, Ph.D.
2006 Nobel Laureate
University of Massachusetts Medical Center
Return to the RNAi World: Rethinking Gene Expression, Evolution and Medicine



Saturday, August 18


8:00 - 8:45 Andrzej Bartke, Ph.D.
Southern Illinois University School of Medicine
Growth Hormone Signaling, Glucose Homeostasis, and Aging


8:45 - 9:30 Shin-ichiro Imai, M.D., Ph.D.
Washington University School of Medicine
Invitation to the NAD World: Mammalian Sirt1 and NAD Biosynthesis in Aging and Metabolism


9:30 - 10:15 Eric Verdin, M.D.
J. David Gladstone Institutes
Role of a SIRT3, a Sir2-related Mitochondrial Protein Deacetylase, in Aging