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Friday Evening Lecture Series
08/05/11
Lillie Auditorium, 8:00 PM
Glassman Lecture - "The Broad Spectrum of Prion-Like Diseases and the Quest for Therapeutics"
Stanley B. Prusiner, University of California, San Francisco; Nobel Prize for Physiology or Medicine, 1997
Introduction by Gary Borisy
Lecture Abstract:
Dr. Prusiner discovered an unprecedented class of pathogens that he named prions. Prions are infectious proteins that cause neurodegenerative diseases in animals and humans. Dr. Prusiner discovered a novel disease paradigm when he showed prions cause disorders in humans that manifest as (1) sporadic, (2) inherited and (3) infectious illnesses. Dr. Prusiner demonstrated that prions are formed when a normal, benign cellular protein acquires an altered shape. His proposals of multiple shapes or conformations for a single protein as well as the concept of infectious proteins were considered heretical. Prior to Dr. Prusiner’s discoveries, proteins were thought to possess only one biologically active conformation. Remarkably, the more common neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases have been found over the past two decades to be, like the prion diseases, disorders of protein processing. Dr. Prusiner’s current research focuses on determining the atomic structure of prions, deciphering the mechanism of replication and defining how biological properties are enciphered in prion strains. In addition, he is developing drug discovery aimed at producing therapeutics that retard neurodegeneration in Alzheimer’s, Parkinson’s and prion diseases as well as the frontotemporal dementias.
Stanley Prusiner, M.D., is Director of the Institute for Neurodegenerative Diseases and Professor of Neurology at the University of California, San Francisco where he has worked since 1972. He received his undergraduate and medical training at the University of Pennsylvania and his postgraduate clinical training at UCSF. From 1969-72, he served in the U.S. Public Health Service at the National Institutes of Health. Editor of 12 books and author of over 450 research articles, Prusiner’s contributions to scientific research have been internationally recognized.
Dr. Prusiner is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society, and a foreign member of the Royal Society, London. He is the recipient of numerous prizes, including the Potamkin Prize for Alzheimer’s Disease Research from the American Academy of Neurology (1991); the Richard Lounsbery Award for Extraordinary Scientific Research in Biology and Medicine from the National Academy of Sciences (1993); the Gairdner Foundation International Award (1993); the Albert Lasker Award for Basic Medical Research (1994); the Paul Ehrlich Prize from the Federal Republic of Germany (1995); the Wolf Prize in Medicine from the State of Israel (1996); the Keio International Award for Medical Science (1996); the Louisa Gross Horwitz Prize from Columbia University (1997); the Nobel Prize in Physiology or Medicine (1997); and the National Medal of Science (2009).
Dr. Prusiner holds 50 issued or allowed United States patents, all of which are assigned to the University of California.
Dr. Gary Borisy will introduce Dr. Stanley Prusiner. Dr. Borisy is the President and Director of the Marine Biological Laboratory in Woods Hole. He is a molecular cell biologist best known for his research directed at understanding how cells crawl, how they divide and how they acquire their shape, all fundamental processes underlying cell function in health and disease. He has authored or co-authored over 200 papers and is a recipient of numerous awards including an NIH MERIT Award, the Carl Zeiss Award from the German Society for Cell Biology, and the Distinguished Alumni Award of the University of Chicago. He is a member of the National Academy of Science, the American Academy of Arts and Sciences and a past President of the American Society for Cell Biology.
About the Glassman Lecture:
The Glassman Lecture is held in honor of the late Harold N. Glassman who left a generous bequest to the MBL which resulted in the establishment of the Harold N. Glassman fund, the income from which is used to support an annual Friday Evening Lecture on an important topic in biological research.
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