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The Trager Lectures
A Symposium to Honor a Lifetime of Contributions by Dr. William Trager to the Study of Malaria
Saturday, June 18, 2005 - Lillie Auditorium, 2:00 PM.
Plasmodium: Discovering principles of parasitism for the design of drugs and vaccines
Irwin W. Sherman, Ph.D., Professor of Biology Emeritus, Department of Biology, University of California, Riverside
Lecture Abstract:
Our work has shown that cryptic regions of band 3 play a role in cytoadherence/sequestration. We have used synthetic peptides based on band 3 sequences (named pfalhesin and DBR) to block cytoadherence and have identified the endothelial cell receptor for pfalhesin (HPLQKTY) to be the type 3 repeat of thrombospondin. The endothelial cell receptor for DBR (YETFSLIKIFQDH) is CD36. Exposure of cryptic regions of band 3 is a result of clustering to produce a conformational change in the band 3 protein. Implications of these findings for the development of therapies and vaccines will be discussed.
Irwin W. Sherman is a Professor of Biology Emeritus at the University of California, Riverside. He has been on the faculty there since 1962. Dr. Sherman received his B.S. in Biology from the City College of New York, his M.S. and Ph.D. in Biology from Northwestern University, and served as a post-doctoral fellow in the U.S. Public Health Service at the Rockefeller University from 1960 to 1962. He was a laboratory assistant at the Marine Biological Laboratory (MBL) in the summer of 1958 and later was an instructor in the MBL's Invertebrate Zoology course from 1963 to 1968. Dr. Sherman is a member of the American Association Advancement of Science and the American Society of Tropical Medicine and Hygiene and has received numerous awards throughout his career. He is currently on the editorial board of the Journal of Eukaryotic Microbiology and is the author of more than 150 publications and two books including Biology: A Human Approach, and The Invertebrates: Function and Form. He is also the editor of Malaria: Parasite Biology, Pathogenesis, Protection. He is currently editing Molecular Apprroaches to Malaria, to be published in September 2005.
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